2024

• Behrendt A, Stindt J, Pfister ED, Grau K, Brands S, Dröge C, Stalke A, Bonus M, Sgodda M, Cantz T, Bastianelli A, Baumann U, Keitel V, Gohlke H. Impaired transitioning of the FXR ligand binding domain to an active state underlies a PFIC5 phenotype. Available as preprint at bioRxiv 2024, DOI: 10.1101/2024.02.08.579530. (RP1, RP2a, RP2b, RP3, CR)
• Lehr K, Lange UG, Hipler NM, Vilchez-Vargas R, Hoffmeister A, Feisthammel J, Buchloh D, Schanze D, Zenker M, Gockel I, Link A, Jansen-Winkeln B. Prediction of anastomotic insufficiency based on the mucosal microbiome prior to colorectal surgery: a proof-of-principle study. Sci Rep 2024. 14:15335. PMID: 38961176: (RP5)
• Van-Wehle T, Vital M. Investigating the response of the butyrate production potential to major fibers in dietary intervention studies. NPJ Biofilms Microbiomes 2024. 10:63. PMID: 39080292 (RP5)
• Happ E, Schulze K, Afrin Z, Woltemate S, Görner P, Ziesing S, Schlüter D, Geffers R, Winstel V, Vital M. Gut microbiota-derived butyrate selectively interferes with growth of carbapenem-resistant Escherichia coli based on their resistance mechanism. Gut Microbes 2024. 16:2397058. PMID: 39292563 (RP5)

2023

• Herta T, Dröge C, Herber A, Keitel V, Berg T. Odevixibat treatment in an adult patient with advanced icteric progressive cholestatic liver disease. J HEP Rep 2023;6:100978; PMID: 38375459. (RP1, CR)
• Stindt J*, Dröge C*, Lainka E, Kathemann S, Pfister ED, Baumann U, Stalke A, Grabhorn E, Shagrani MA, Mozer-Glassberg Y, Hartley J, Wammers M, Klindt C, Philippski P, Liebe R, Herebian D, Mayatepek E, Berg T, Schmidt-Choudhury A, Wiek C, Hanenberg H, Luedde T, Keitel V. Cell-based BSEP trans-inhibition: A novel, non-invasive test for diagnosis of antibody-induced BSEP deficiency. JHEP Rep 2023; 5:100690 *contributed equally, PMID: 37425215. (RP1, RP2b, CR)
• Dröge C, Götze T, Behrendt A, Gohlke H, Keitel V. Diagnostic workup of suspected hereditary cholestasis in adults: a case report. Explor Dig Dis 2023;2:34-43 (RP1, RP2a, CR)
• Stalke A, Behrendt A, Hennig F, Gohlke H, Buhl N, Reinkens T, Baumann U, Schlegelberger B, Illig T, Pfister ED, Skawran B. Functional characterization of novel or yet uncharacterized ATP7B missense variants detected in patients with clinical Wilson's disease. Clin Genet 2023;104:174-185. doi: 10.1111/cge.14352; PMID:37157876. (RP1, RP2a)

2022

• Pfister ED, Dröge C, Liebe R, Stalke A, Buhl N, Ballauff A, Cantz T, Bueltmann E, Stindt J, Luedde T, Baumann U, Keitel V. Extrahepatic manifestations of progressive familial intrahepatic cholestasis syndromes: presentation of a case series and literature review. Liver Int 2022;doi:10.1111/liv.15200; PMID: 35184362. (RP1, RP3, CR)
• Behrendt A, Golchin P, König F, Mulnaes D, Stalke A, Dröge C, Keitel V, Gohlke H. Vasor: Accurate prediction of variant effects for amino acid substitutions in multidrug resistance protein 3. Hepatol Commun 2022 6:3098-3111. doi: 10.1002/hep4.2088. PMID: 36111625. (RP1, RP2a, RP2b, CR)
• Stalke A, Sgodda M, Cantz T, Skawran B, Lainka E, Hartleben B, Baumann U, Pfister ED. KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease. J Pediatr 2022; 240:284-291e9. PMID: 34555379. (RP1, RP3, CR)

2021

• Eggenschwiler R, Gschwendtberger T, Felski C, Jahn C, Langer F, Sterneckert J, Hermann A, Lühmann J, Steinemann D, Haase A, Martin U, Petri S, Cantz T. A selectable all-in-one CRISPR prime editing piggyBac transposon allows for highly efficient gene editing in human cell lines. Sci Rep 2021; 11:22154. PMID: 34773059 (RP3)
• Jeyaraj R, Bounford KM, Ruth N, Lloyd C, MacDonald F, Hendriksz CJ, Baumann U, Gissen P, Kelly D. The Genetics of Inherited Cholestatic Disorders in Neonates and Infants: Evolving Challenges. Genes (Basel) 2021; 12:1837. PMID: 34828443. (CR)
• Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Hohne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, Garcia- Beccaria M, Gabernet G, Nahnsen S, Mallm JP, Vogel M, Schoonjans K, Lautwein T, Köhrer K, Häussinger D, Luedde T, Heikenwalder M, Keitel V. Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis. J Hepatol 2021; 75:634-646. PMID: 33872692. (RP2b)
• Liebe R, Esposito I, Bock HH, Vom Dahl S, Stindt J, Baumann U, Luedde T, Keitel V. Diagnosis and management of secondary causes of steatohepatitis. J Hepatol 2021; 74:1455-1471. PMID: 33577920. (RP2b, CR)